ABSTRACT
Objective To study the effect of topical application of tranexamic acid(TXA)in total hip arthroplasty(THA).Methods A total of 63 patients with unilateral THA were enrolled in this study from November 2014 to March 2016.All patients were randomly divided into group A(n=37)and group B(n=26).Group A was injected with 2.0 g TXA(dissolved in 10 mL saline)in the joint cavity tube after the end of the surgical dressing.Group B injected the same amount of saline.The hemoglobin,hematocrit,postoperative blood loss,blood transfusion,blood transfusion and replacement of 24,48,72 h after the replacement,24,48 and 72 h after fibrinogen,prothrombin time and activation of part of the thromboplastin time,lower extremity deep vein ultrasound between the two groups were compared.Results The hemoglobin,hematocrit,postoperative blood loss,blood transfusion and blood transfusion were significantly better in group A than those in group B at 24,48 and 72 h after replacement(P0.05).Conclusion The local application of TXA group can significantly reduce the THA perioperative blood loss without the increase of the risk of deep vein thrombosis.
ABSTRACT
Artificial hip replacement is the most universal and effective means for treating terminal stage disease of hip joint. At present, the metal, ceramic, organic polymer and composite materials used in hip prosthesis have various problems. Metal ions or particles which released from metal materials can increase the wear rate and have potential toxicity to human. Polymers results in arthroplasty failure by bone resorption with macrophages. Bioceramic has poor mechanical property, and cause bioactivity decrease at over high temperature. Accordingly, the biocompatibility of hip prosthesis materials can be enhanced by improving design and manufacturing technology, increasing abradability and mechanical property, enhancing associativity, decreasing stress shielding, which can prolong serve life of the prosthesis.